Credit: CC0 Public Domain

New research in mice finds that deficiency in one small component of a signaling pathway may protect against artery stiffening and subsequent kidney disease associated with a high-fat, high-sugar diet. The study is published in the American Journal of Physiology-Renal Physiology.

Consuming a —typically high in fat and refined carbohydrates, including sugar—is associated with a stiffening of the arteries that is a hallmark of heart and kidney disease. Previous research has found that artery stiffening begins in the cells that line the blood vessels (endothelium) and that following a western accelerates this