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Florida on Saturday hit a new daily coronavirus case record of nearly 10,000—a dramatic setback that several other states are also experiencing as economic reopenings clash with public health realities.

Infections are also up in some other parts of the world that have reopened, including the Czech Republic, which recently marked its biggest spike in virus cases in months.

The US leads the world in COVID-19 cases by far, accounting for 2.5 million of the global total of nearly 9.9 million since the virus emerged late last year in China.

US deaths now exceed 125,000, approximately