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CAR-T cell therapy is a new and revolutionary weapon against cancer: T cells are isolated from the patient’s blood for genetic modification and then infused back into the patient to attack cancer cells. Researchers from the Medical University of Vienna have now determined why CAR-T cells do not destroy tumor cells that express tumor antigens in small numbers. Their study, published in Nature Immunology, shows that CAR-T cells fail to initiate adequate intracellular signaling when facing low antigen densities, even though they bind the antigen in a highly efficient manner.

CAR-T cells are T cells