According to scientific estimations, humans are exposed to 10,000 to 100,000 environmental and exogenous compounds in an individual lifetime. Various molecules as well as co-exposures can impact drug efficacy. Credit: Pixabay

Humans are exposed to various environmental or dietary molecules that can attenuate or even increase the effect of therapeutic drugs. Studies on the industrial chemical bisphenol A and the phytoestrogen genistein, for example, have shown drug-exposome interactions. However, interactions between exposures and therapeutic agents have not been systematically investigated to date, conclude chemists Benedikt Warth and Manuel Pristner at the University of Vienna in a review article published in