(HealthDay)—The number of adverse drug reactions (ADRs) associated with hydroxychloroquine and chloroquine more than doubled in 2020 compared with 2018 and 2019, according to a research letter published online Jan. 26 in the Annals of Internal Medicine.

Justine Perez, Pharm.D., from the Grenoble Alpes University Hospital in France, and colleagues quantified the change in number and type of reported ADRs associated with hydroxychloroquine and chloroquine since the beginning of the COVID-19 pandemic compared to 2018 and 2019.

A total of 21,305 reports of 152,201 suspected ADRs concerning chloroquine and hydroxychloroquine were extracted from the U.S. Food and Drug Administration