Ball-and-stick mannequin of the testosterone molecule, C19H28O2, as discovered within the crystal construction of testosterone monohydrate. Credit score: Ben Mills/Wikipedia

Consuming a weight loss program excessive in pro-inflammatory meals—together with meals that comprise refined carbohydrates and sugar in addition to polyunsaturated fat—could also be related to elevated odds of creating testosterone deficiency amongst males, suggests a examine in The Journal of Urology, Official Journal of the American Urological Affiliation (AUA).

The chance of testosterone deficiency is best in males who’re overweight and devour a refined weight loss program that scores excessive on the dietary inflammatory index (DII), in keeping with the brand new analysis by Qiu Shi, MD, Zhang Chichen, MD, and colleagues of West China Hospital, Sichuan College, Chengdu, Sichuan Province, China. “Whereas these findings don’t show causation, they do assist earlier analysis suggesting a pro-inflammatory weight loss program can contribute to testosterone deficiency, amongst different probably debilitating well being points,” Drs. Qiu and Zhang remark.

Does weight loss program affect testosterone ranges? New examine discovers hyperlink

Testosterone is a male intercourse hormone that performs necessary roles in replica and sexual perform. Nonetheless, 20 to 50 % of US males have testosterone deficiency—outlined as a testosterone stage lower than 300 ng/dL (nanograms per deciliter). Signs of testosterone deficiency might embrace low libido, decreased vitality, poor focus and despair. Testosterone deficiency can be related to power illnesses, together with heart problems and weight problems.

Human and animal research have linked testosterone deficiency with elevated ranges of irritation within the physique. Males with low testosterone have greater ranges of pro-inflammatory cytokines: small proteins launched by cells throughout harm, an infection or in response to inflammatory elements within the atmosphere. The DII has emerged as a instrument for assessing the inflammatory potential of an individual’s weight loss program, significantly in relation to different markers of well being.

The researchers studied the affiliation between the DII and testosterone deficiency in 4,151 males from the Nationwide Well being and Diet Examination Survey, all of whom accomplished a 24-hour dietary interview and underwent intercourse hormone testing. Every participant’s DII was calculated primarily based on the dietary historical past interview.

Calculated DII scores ranged from -5.05 (most anti-inflammatory) to +5.48 (most pro-inflammatory). Common whole testosterone stage was 410.42 ng/dL in males with essentially the most pro-inflammatory weight loss program versus 422.71 ng/dL in these with essentially the most anti-inflammatory weight loss program. General, about 26 % of the boys had testosterone deficiency.

For males with essentially the most pro-inflammatory weight loss program, the percentages of testosterone deficiency have been about 30 % greater in comparison with males with essentially the most anti-inflammatory weight loss program. The associations remained vital after adjustment for different traits, together with physique mass index and smoking.

In a completely adjusted evaluation, the danger of testosterone deficiency was best in males who have been overweight and had the next DII. For this group, the percentages of testosterone deficiency have been almost 60 % greater in comparison with males with weight problems who had a decrease DII.

Drs. Qiu, Zhang, and coauthors notice some necessary limitations of their examine, together with the truth that the DII was calculated primarily based on a restricted variety of anti-inflammatory and pro-inflammatory meals parameters.

“Our outcomes recommend males who eat a pro-inflammatory weight loss program, significantly those that are overweight, usually tend to have testosterone deficiency,” Drs. Qiu and Zhang remark. “Since males with weight problems doubtless already expertise power irritation, physicians ought to pay attention to contributing elements, like weight loss program, that might doubtless worsen this irritation and contribute to the danger of different well being situations, corresponding to diabetes and coronary heart illness.”

Drs. Qiu and Zhang and colleagues name for additional research to confirm the causal relationship between DII and testosterone deficiency. In addition they recommend that consuming a extra anti-inflammatory weight loss program “may very well be a possible methodology to scale back the collected inflammatory burden, [potentially] resulting in an elevated testosterone stage.”


Low-fat weight loss program linked to decrease testosterone ranges in males


Extra info:
Chichen Zhang et al. The Affiliation between Dietary Inflammatory Index and Intercourse Hormones amongst Males in the USA, Journal of Urology (2021). DOI: 10.1097/JU.0000000000001703

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